Background: Dopamine transporter (DAT) and ␣-synuclein interact, but the mode and mechanism of ␣-synuclein regulation of DAT activity are less known. Results: Elevated intracellular ␣-synuclein alters DAT-mediated currents and activity that are abrogated by DAT blocker and are absent with heat-inactivated ␣-synuclein. Conclusion: DAT/␣-synuclein interaction at the cell surface alters the ionic coupling of DAT. Significance: This interaction modulates dopamine transmission and thus neuronal function.

For more information on the USGS-the Federal source for science about the Earth, its natural and living resources, natural hazards, and the environment-visit http://www.usgs.gov or call 1-888-ASK-USGS For an overview of USGS information products, including maps, imagery, and publications, visit http: //www.usgs.gov/pubprod To order this and other USGS information products, visit