Intermittent irrigation can save water use in rice cultivation, which is essential, especially during the dry season. This study aims to improve the physiology of the growth and yield of rice in various varieties by applying intermittent irrigation. The research was conducted from February to June 2019 in the experimental field of the Faculty of Agriculture, Universitas Muhammadiyah Yogyakarta. The research used a factorial experimental method 3 x 4 strip plots arranged in a Completely Randomized Block Design with three replications. The factor I rice varieties consist of Cempo Merah, Inpari 23, Sintanur, and Inpari 42. Factor II is the irrigation system consisting of continuous flooding, ten days of inundation, five days of drying, seven days of inundation, and three days of drying. There is an interaction between types of irrigation and rice varieties on the number of tillers. In Ten-day watering five-day drying, Sintanur and Inpari 42 variety produce more tillers than Inpari 23. On Seven days watering five-day drying, the Inpari 42 variety produces more tillers than Inpari 23. There are the differences in the responses of various rice varieties to the Specific Leaf Weight and yield. Specific Leaf Weight rice Cempo Merah varieties are higher than, Inpari 23, Sintanur and Inpari 42. Rice yield of Inpari 42 variety is higher than Cempo Merah, Inpari 23, and Sintanur varieties. Roots with watering seven days watering, three days of drying is longer than Ten-day watering five-day drying. Roots with watering Ten-day watering five-day drying is longer than conventional.