Background: Seroma is the most significant complication that occurred after mastectomy, happen in 25% until 60% cases. Seroma are not life threatening complications, but can lead to serious morbidity, prolonged hospital stay and delay adjuvant therapy. Autologous Fibrin Glue is a hemostatic agent that can accelerate fibrin thread formation, stop vascular oozing and decrease dead space. This research was performed to evaluate Autologous Fibrin Glue function in lowering seroma volume at 14th days after simple mastectomy. Methods: This research is a clinical trial to compare average seroma volume between advance stage locally breast carcinoma patients group which are given Autologous Fibrin Glue on the surface of surgical wound, 14 days after simple mastectomy (trial group) and control group (without special treatment) with ultrasonography. Result: From 42 patients who met the inclusion criteria, divided into 2 groups, 21 patients were given Autologous Fibrin Glue on the surgical wound surface in a simple mastectomy procedure, 21 patients as a control group. The number of seromas in the treatment group was measured using ultrasound on the 14th day, fewer meaningfully than the control group, the median seroma volume in the treatment group was 9,30 mL and median seroma volume in the control group was 20.90 mL. The P value in the variable number of seroma is smaller than 0.05 (P. < 0.05) which means significant, the number of seromas measured using ultrasonography (USG) on the 14th day, fewer meaningfully in the treatment group. Conclusion: Subjects that was given Autologous Fibrin Glue on the surface of surgical wound after simple mastectomy has a lower volume of seroma compared to control group.

Background: Seroma is arguably the most significant complication that can happen after mastectomy. Although seroma is not a life-threatening complication, this condition can lead to severe morbidities. This situation can cause prolonged hospital stays and delayed adjuvant therapy. In this regard, autologous fibrin glue is a hemostatic agent that can accelerate fibrin formation, stop vascular oozing, and decrease dead space. Therefore, this research was performed to evaluate autologous fibrin glue function in lowering seroma volume after mastectomy and shortening the length of hospital stay.Methods: This randomized control trial research was designed to compare the effect of autologous fibrin glue to a control group that did not receive autologous fibrin glue. Seroma volume was calculated every 24 hours. The drains were then removed after the production of seroma less than 30 mL/24 hours.Results: We recruited 20 patients for each of the two groups who met the inclusion criteria. Age, histopathology type, breast cancer stage, number of lymph nodes, and tumor size did not significantly differ. However, patients in the fibrin glue group had significantly lower cumulative drain production. The median seroma volume in the treatment group was 9.30 mL, while the median in the control group was 20.90 mL (p < 0.05).Conclusions: Autologous fibrin glue significantly decreased seroma formation and length of hospital stay.