The 2-aminothiazole compounds are medicinally important agents due to their broad spectrum of biological activities. This study aims to design new 2-aminothiazole derivatives, docking, and synthesis via several steps and identified d concerning their The bioactivities of the synthesized compounds were evaluate using physical and spectroscopic techniques. Escherichia , Enterobact aerogenes were screened against five bacterial strains, antimicrobial activities against Candida and two types of fungal strain Pseudomonas aeruginosa, Staphylococcus aureus , Enterococcus faecalis , coli . Cryptococcus neoformans var. grubii and albicans K albicans. C.