hospitals are regional tertiary hospital that serves more than six governors providing service to a population of more than nine million people living in the east of Egypt. Control group: number and characters of control group were selected to adapt with age and sex for each cancer group. Cases: Patients included in this study attended Medical Oncology department for the period of June 2013 to June 2015 and were confirmed to have cancer, clinically, laboratory and radiologically. Inclusion criteria: Patients suffering from solid tumors where association with oncogenic infectious agent were suspected HCC, Urinary bladder cancer, Gastric carcinoma, Head and neck and cancer cervix Exclusion criteria: Patient suffering from hematological malignancies or other solid tumors. Further investigations were done to identify the causing infectious agent, if present. These investigations include:

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