Cypermethrin is synthetic pesticide that has been in use for more than a decade with low mammalian toxicity. This study was carried out to evaluate the effect of cypermethrin on some biochemical parameters in blood and both muscle and liver tissue. Adult male rats were used to determine the median lethal dose within 24 hours and been relied on them to take the 1/10 of the median lethal dose to expose the skin of rats daily for periods of 4 weeks. The results showed that cypermethrin caused a significant increase in levels of glucose, creatinine,urea, uric acid and malondialdelyde and activities of aspartate amino transferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase in the serum. There were also reduced the levels of total protein, albumin, globulin and glutathione in the serum. Glycogen levels in both liver and muscle decreased significantly. It is concluded from the present study that daily skin exposure to cypermethrin induced alterations in some biochemical parameters in blood and tissues of liver and muscle in rats.

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