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The effect of Gamma radiation on kidney tissues of male mice before and after Nigella sativa seeds alcoholic extractions (50mg/kg B.W.) supplementation for 10, 20 and 30 days was investigated. Histopathological examination carried out in this study indicated that a dose 125 rad /day of Gamma radiation causes different degree of damage in the morphology of kidney tissues includes cytoskeleton disturbance, necrosis, apoptosis, nuclear damage, cellular death, vacullation, Bowman capsules damage and Hemorrhage. The histological observations also revealed important differences between control and tested individuals depending on the irradiation duration. On the other hand the results showed that kidney tissues recovered to almost restored the natural architecture in mice treated with 50mg/keg B.W. Nigella sativa seeds alcoholic extractions pre exposed to Gamma Ray at (10) days but at (20) days the recovery is les pronounce then the mice which exposed to gamma ray for (30) days, as compared with control group and all duration of exposure to radiation. these results indicate that Nigella sativa seeds have protective role against Gamma rays.

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