Purpose: To evaluate the safety and efficacy during at least 1-year follow-up of visian implantable collamer lens ICL to correct high anisometropia in amblyopic children who were non-compliant with spectacles or contact lenses. Methods:A prospective non comparative interventional case series study of 12 eyes of 12 children with high anisometropia who underwent ICL implantation (phakic posterior chamber IOL). Patient age at the time of implantation ranged from 2 to 15 years. Mean preoperative spherical equivalent refraction was -10 diopters (D). Mean logMAR uncorrected visual acuity (UCVA) was .03 and corrected distance visual acuity (CDVA) was .3 occlusion therapy was done after surgery in all cases and follow up for a period 1-2 years was done in all cases. Cases with less than 1 year follow up were excluded from the study.Results: UCVA and CDVA improved in all children. At 12 months, mean decimal UCVA and CDVA were 0.6 and 0.8 respectively (P value less than .01). No loss of CDVA was detected in any patient. Endothelial cell loss was comparable to normal age related changes in endothelial cell count. Conclusion:ICL provided significant improvement in visual acuity and spherical equivalent, which suggests that it may be effective, safe and predictable for correcting pediatric refractive errors producing anisometropic amblyopia.