Objective: was to evaluate the effect of different surface treatments on the tensile bond strength of two different types of artificial teeth to CAD/CAM denture base. Materials and Methods: 160 specimens were fabricated and divided into two main groups according to the denture base material; Group (A) for conventional denture base (HCAR denture base) and Group (B) for CAD/ CAM denture base. According to the artificial teeth each group of denture base was subdivided into two subgroups, subgroup (I) for conventional acrylic denture teeth and subgroup (II) for composite resin denture teeth. According to the surface treatment each subgroup of artificial teeth was subdivided into four subgroups as following: Subgroup 1: no surface treatment (control group). Subgroup 2: sandblasting with 250-micron alumina particles. Subgroup 3: roughening with a diamond bur. Subgroup 4: specimens were treated by dichloromethane. Results: The results showed that Pre-polymerized CAD\CAM acrylic resin denture bases specimens exhibited non-significant lower bond strength than HCAR denture base specimens (p>0.05), acrylic resin denture teeth demonstrated higher bond strength to denture bases than composite resin denture teeth (p≤0. 05). Conclusion: the Pre-polymerized CAD\CAM acrylic resin denture bases specimens exhibited non-significant lower bond strength than HCAR denture base specimens, and acrylic resin denture teeth demonstrated higher bond strength to denture bases than composite resin denture teeth, the bond strength of the denture teeth treated with both dichloromethane and sandblasting was improved while the bond strength of the denture teeth treated by roughening with diamond bur was decreased.