Cancer is among the leading causes of death globally. Despite advances in cancer research, a full understanding of the exact cause has not been established. Recent data have shown that the microbiome has an important relationship with cancer on various levels, including cancer pathogenesis, diagnosis and prognosis, and treatment. Since most studies have focused only on the role of bacteria in this process, in this article we review the role of fungi—another important group of the microbiome, the totality of which is referred to as the “mycobiome”—in the development of cancer and how it can impact responses to anticancer medications. Furthermore, we provide recent evidence that shows how the different microbial communities interact and affect each other at gastrointestinal and non-gastrointestinal sites, including the skin, thereby emphasizing the importance of investigating the microbiome beyond bacteria.

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Patients who had never received any earlier treatment for periorbital hyperpigmentation. c Subjects willing to comply with the requirements of the study, including sequential photography, follow-up visits, and giving written informed consent. (2) Exclusion criteria: c Critical thrombocytopenia (,50,000/ml). c Hemodynamic instability. c Chronic medical illness (e.g., diabetes, chronic infections, and blood dyscrasias). c Local inflammation or infection at the site of the procedure. c Use of anticoagulants or nonsteroidal anti-inflammatory drugs (NSAID) within 48 hours of procedure, corticosteroid injection at treatment site within one month, or systemic use of corticosteroids within 2 weeks. c Recent fever, illness, or cancer. c Hemoglobin level , 10 g/dL.A simple randomization method was used to divide participants into 2 equal groups: Group A treated with PRP and Group B treated with autologous fat injection.