The critical nitrogen (N) dilution curve, which expresses whole-plant critical N concentration as a function of shoot biomass, can be used as a N management diagnostic tool for cereals. The objectives of this research were to develop a critical N dilution curve for wheat grown in calcareous soils and to formulate a model for estimating N fertilizer requirement of wheat crop at different growth stages. Six N fertilization rates (0–250 kg N ha−1) were used to induce variability in plant growth throughout six site-years (three locations at West Delta of Egypt and two seasons [2020/21-2021/22]). Aboveground shoot biomass (W; Mg DM [dry matter] ha−1) and N concentration (Nc; g kg−1 DM) were determined on five sampling dates during the growing season. A critical N dilution curve was developed as: $${N}_{\mathrm{c}}=50.141 {\mathrm{W}}^{-0.424}$$ N c = 50.141 W - 0.424 . The Nc dilution curve was then used to develop a N fertilizer topdressing strategy. The study relied on N nutrition index inferred from the Nc based on N uptake, and instead of relying on a single N recovery efficiency coefficient, a variable N recovery efficiency was developed. This approach increased the hypothetical N requirements at low N application rates while decreased requirements at high N application rates, implying that the Nc dilution curve can be used successfully to estimate the rates of supplemental N application. The developed strategy will provide a solid basis for precisely managing N fertilizer, though challenge ahead at the farm level will be in determining the actual shoot biomass and N concentration.