Background: Wound healing is accelerated and improved by using honey dressing due to its antioxidant, anti-bacterial and anti-inflammatory properties . Purpose: to determine the effect of honey dressing on open wound healing and patient's satisfaction among surgical patients. Research Design: A quasi-experimental designs utilized for this study. Setting: General surgical department of menoufia university hospital. Subjects: A purposive sample of 90 adult patients with open wound, were selected and divided alternatively and randomly into two equal groups (45 study group -45 control group). Instruments: Three instruments were used for data collection: Structural interviewing questionnaire,Bates-Jensen wound assessment Tool, Patient's satisfaction assessment sheet.Results:There was significant improvement in wound healing and patient's satisfaction among study group than control group. Majority of the study group of the current study were satisfied with honey dressing, about 37 (82.2%) patients were satisfied while only 8 (17.8%) patients were partially satisfied. Conclusions: The honey dressing was safe and effective on wound healing and didn't cause any side effects, accelerate wound healing, and increase patient's satisfaction. Recommendations: Honey dressing should be used as an alternative therapy for wound healing as it safe, cost effective, accelerate wound healing, and promote patient comfort.