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The use of recycled tire rubber in asphalt pavements to improve the overall performance, economy, and sustainability of pavements has gained considerable attention over the last few decades. Several studies have indicated that recycled tire rubber can reduce the permanent deformation of flexible pavements and enhance its resistance to rutting, reduce pavement construction and maintenance costs, and improve the resistance to fatigue damage. This paper provides a systematic and critical overview of the research on and practice of using recycled tire rubber in asphalt pavements in terms of engineering properties, performance, and durability assessment. This critical analysis of the state-of-the-art should enhance the understanding of using recycled tire rubber in asphalt pavements, define pertinent recommendations, identify knowledge gaps, and highlight the need for concerted future research.