| This study was designed to evaluate the ameliorative role of L-carnitine and/or sitagliptin on dyslipidemia induced by oral administration of 0.75% hydrogen peroxide in male rats. Thirty five (35) adult male rats were randomly and equally divided into five groups (C, T1, T2, T3 and T4) and were treated for 60 days as following: Group C (Control group), rats in all treated groups from T1 to T4 were given 0.75% H 2 O 2 in drinking water. In addition to H 2 O 2 , 100mg/kg B.W of L-carnitine and 1.5mg/kg. B.W of sitagliptin were administered orally to rats in groups T2 and T3 respectively, while rats in group (T4)