No abstract

The antibacterial activity of cobalt (II) complexes with some heterocyclic derivatives were investigated in vitro against Staphylococcus aureus, Escherichia coli and Enterochoaco. Applying the disc method we mesasured diameters of the inhibition zone around disc which are previously wetted with N,N‐DMF solution of compounds (1 – 5) in concentration 1mg/l, 0.5mg/l and 0.1mg/l.Comparing the inhibitory activities of the tested complexes, it was found that these complexes were more active than heterocyclic compounds (A – E).

A series of some new coumarin derivatives and their Cu(II) complexes have been synthesized and characterized by a variety of physicochemical techniques. The ligands and its metal complexes are screened for their in vitro antibacterial activity against Escherichia coli and Enterochoaco.The studies demonstrated that metallation can increase the antibacterial activity rather than the free ligand.