Reflects on the best approach of the paradigms in nursing research, which allows human phenomena to emerge and through them generate knowledge for this discipline. The systematic review was carried out of 25 documents, analyzing the hermeneutical positivist and interpretive approach to nursing research. According to the analyzed documents and in knowledge of the multiplicity and multidimensionality of phenomena related to the care of the human health experience, which is the object of study of nursing, one of these two paradigms could not be qualified as the best, since it would be foolish accepting one of them or thinking that one is better than another, even more so at the time science is currently going through. Paradigms will quantitative or positivist and qualitative or interpretive hermeneutic prevail to the extent that nursing science requires it.