Objective: The epidemiological features of the cervical cancer (CC) incidence and its spatial and temporal assessment in Kazakhstan were studied. Methods: The retrospective study was done for the period 2009-2018. Descriptive and analytical methods of oncoepidemiology were used. Results: During the study period, 16,441 new cases of CC were registered. The average annual crude and age-standardized incidence rate were 18.6±0.5 and 17.7±0.4 cases per 100,000 population of female, respectively, and their trends tended to increase (Т up =+2.3%; R 2 =0.708 and Т up =+1.9%; R 2 =0.615, respectively). The analysis of ASIR showed unimodal growth with a peak at 50-54 years -45.3±1.1 cases per 100,000 population of female. Trends of ASIR decreased up to 30 years (T down =−1.8%; R 2 =0.111) and 35-59 years (T down =−0.9%; R 2 =0.103), in other age groups the trends increased, and were most pronounced in 40-44 (Т up =+4.1%; R 2 =0.878) and 65-69 years (Т up =+4.4%; R 2 =0.537). Trends in ASR of СС tended to grow in almost all regions, with higher levels in Mangystau (Т up =+4.1%; R 2 =0.482) and Aktobe (Т up =+6.3%; R 2 =0.846) regions. The cartograms of ASR per 100,000 population of female were allocated according to the following criteria: low -up to 16.3, averagefrom 16.3 to 19.2, high -above 19.2. The results of the spatial analysis showed the regions with a higher levels of CC incidence rate per 100,000 population of female: East Kazakhstan (19.8), Aktobe (20.0), Almaty (20.1), Kostanay region (20.9), Atyrau (21.7) regions and Almaty city (22.0). Conclusion: The study of trends of the cervical cancer incidence has the theoretical and practical value: monitoring and evaluation of screening programmes, which are implemented in the country, and conduction of secondary prevention of cervical pathology. Health authorities should consider the obtained results in the in the organization of anti-cancer activities.

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BACKGROUND: According to the modern concept of occupational medicine adopted by the World Health Organization, relationship between health and work is fully established while the levels of physical, chemical and biological harmful production factors can be considered as causative factors of occupational diseases. OBJECTIVE: The aim of this research is to determine the aging rate of at risk workers engaged in chrome ore processing in order to increase their health status and quality of life. METHODS: Biological age (BA) of workers was calculated by measuring the blood pressure, static balance (SB), respiratory rate (RR) and by a questionnaire survey on subjective health assessment (SHA). RESULTS: Based on the workplace certification, we have selected unfavorable professions to assess the rate of aging. We have determined the aging rate, according to which biological age exceeds the official age of workers engaged in chrome ore processing in harmful working conditions. CONCLUSIONS: In harmful working conditions, the aging rate accelerates manifesting in at risk worker's health status with BA-PBA ratio in the range from 2.6 to 7.9 years. Regulators, crusher attendants and refractory men, who work in unfavorable climate, should be the leading professional occupations in terms of proper biological age (PBA) monitoring.

The aim of the work was the study of the biological activity of technologically available flavonoid isolated from Salsola collina Pall. and Serratula coronata L. plants growing on the territory of Kazakhstan, as well as some modified derivatives of flavonoid quercetin and crude extracts. The method of acute hypoxia was applied in experiment to determine antioxidant activity of modified flavonoid and plant extracts. The results of in vivo bio screening on antioxidant activity have shown that quercetin and dry extracts of Serratula coronata L., as well as the extracts of Salsola Collina Pall. show remarkable antioxidant activity. It was found that the concentration of malondialdehyde in the brain and liver tissues of laboratory rats, which were preventively treated with flavonoids and extracts, is lower than in the control animals and is close to that of the intact group. Quantitative comparison showed that antioxidant effect is more significant in the case of extract of Serratula coronata L. Explanation of the high antioxidant effect in the studied plant of Serratula species lies in the composition of the extract. Feature of the whole extract of Serratula coronata L is the presence of molecules with a diphenyl structure, which opens up the possibility of participation in the reconstruction of biomembranes, lipid‐sensitive processes.

Currently, many studies are conducted, and their results again confirmed the correctness of “nutritional standards”, which recommend at least 5 servings of fruit and vegetables daily. One of the possible prognostic factors of atherosclerosis are s biochemical markers of inflammation like C‐reactive protein (CRP), interleukin‐6 (IL‐6) and alpha‐tumor necrosis factor (TNF alpha). It was established credible feedback the CRP with the consumption of fruits, vitamin C and folate in the diet, IL‐6 ‐ with the consumption of legumes, vegetables, beta‐carotene and vitamin C, alpha‐TNF ‐ beta‐carotene and luteolin. With regard to this indicator of oxidative stress, F2‐isoprostane as then showed an inverse correlation to urinary excretion of the total amount of fruits and vegetables, vitamin C, beta‐carotene and flavonoids. And the greatest beneficial effect on the studied parameters provides the early consumption of fruit and vegetables since youth.According to WHO, the diseases caused by deficiency of nutrients, is approximately 75–80% of all known diseases, and socioeconomic damage is great also. There is a direct and constant lack of even trace amounts of micro‐and macronutrients necessary for normal life, can cause and exacerbate many diseases. To compensate for this condition it is necessary to optimize the introduction of healthy food products.