Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. Authors explored the effects of progressive muscle relaxation (PMR) on depression in females with polycystic ovarian syndrome (PCOS).Methods: In a 4-week study duration in which the intervention was for three times a week, 30 females which were selected according to the inclusion and exclusion criteria received a PMR protocol in which subjects were taught to contract and relax 16 muscle groups. The Becks Depression Inventory (BDI) was taken before and after the intervention as a depression analysis tool.Results: After 4 weeks of intervention, the patients showed significant improvement in depression (P < 0.05).Conclusions: In conclusion, this study suggests that PMR practice is effective in improving depression, in patients with PCOS.