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The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

ments were done in which angiotensin was infused either into the carotid artery or intravenously. It was shown that intracarotid infusions of angiotensin were more potent in stimulating ADH release than intravenous infusions. This was so in spite of the fact that both routes of infusion resulted in the same elevation of blood pressure and neither altered plasma osmolality, sodium concentration, nor hematocrit. Solutions of angiotensin were also perfused through the ventricular cisternal system. All concentrations of angiotensin, from 0.3-443 rig/ml, resulted in significant release of ADH. These data are interpreted to mean that some area of the brain is responsive to local concentrations of angiotensin, such that an increased concentration leads to increased release of ADH.

The literature supports the concept that circadian changes in body temperature reflect changes in the thermoregulatory set point. We were interested in studying the relationship between the circadian rhythm in body temperature and 24-h variations in plasma concentrations of iron, zinc, circulating leukocyte counts, and plasma interleukin 1 (IL-1) activity. Eight healthy men were studied for two separate 48-h sessions. Rectal temperature, plasma iron and zinc concentrations, plasma IL-1 activity, circulating leukocyte counts, and several other blood variables were monitored. Circadian rhythms in temperature, trace metals, and various leukocyte populations were demonstrated. The 24-h pattern of changes in plasma concentrations of iron and zinc approximate an inverse relationship with rectal temperature. Although we were unable to detect any IL-1 activity in human plasma collected at 4-h intervals, the daily changes in plasma trace metal concentrations and the variations in leukocyte populations may provide indirect evidence for a daily variation in local (e.g., in liver) or central nervous system release of IL-1.

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