An isomer-divergent synthesis of naturally occurring pericosines A and B is described starting from a known D-ribose derived ene-diol in 35% and 41% overall yields respectively of which the latter is the best synthetic method reported for pericosine B. The key features of this synthesis include the stereoselective NHK vinylation of the terminal aldehyde to the versatile diolefinic chiral intermediate and elegant conversions of the same to the corresponding final products via RCM (Ring Closing Metathesis).

Zaleplon is licensed for the short-term treatment of insomnia. Excessive usage causes side effects; hence, the drug is controlled. Identifying zaleplon in a drug abuser requires an isotope-labeled internal standard. This work presents a synthesis of stable isotope-labeled internal standard for zaleplon, zaleplon-d 5 , by a five-step synthetic sequence.

Silica gel was found to be an excellent medium for some useful organic transformations under organic solvent-free conditions, such as (1) the Friedel-Crafts-type nitration of arenes using commercial aqueous 69% nitric acid alone at room temperature, (2) one-pot Wittig-type olefination of aldehydes with activated organic halides in the presence of tributyl- or triphenylphosphine and Hunig’s base, and (3) the Morita-Baylis-Hillman reaction of aldehydes with methyl acrylate. After the reactions, the desired products were easily obtained in good to excellent yields through simple manipulation.

This work presents a highly efficient and simple method for the synthesis of bisindolylmethanes, catalyzed by AgBF 4 , with excellent yields. Various substituted aldehydes and ketones with indole under this reaction condition is elucidated. This reaction occurs efficiently under mild reaction conditions, such as are applied with methoxy or furfural, which commonly undergoes cleavage under strongly acidic reaction conditions. The presented approach was suitable for the synthesis of complex systems, such as tetraindolylmethane Tröger's Base.

This study describes the synthesis of deuterium-labelled (7)-4-methyl-2,5-dimethoxyamphetamine (DOM) and (7)-1-(7-methoxy-1,3-benzodioxol-5-yl)propan-2-amine (MMDA). The isotopically labelled compounds are potentially used as internal standards in gas chromatography-mass spectrometry (GC-MS) assays.