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An efficient, general synthesis of 2-substituted thiazolo [4,5-f] C NMR, LR/ HR EI/ FAB/ ESI-MS).The synthesis of thiazolo [4,5-f]isoquinolines constitutes the first synthesis of this class of heteroarenes. Eighteen compounds, covering all three types, were screened for inhibition of COX-1 and COX-2, and some of them showed moderate activities.

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Synthesis of 1-Methyl-2-(hetero)arylbenzimidazoles. -Optimized conditions allow the preparation of a broad spectrum of pharmaceutically interesting target compounds in the presence of the eco-friendly catalyst STA. -(CHAKRABARTY*, M.; MUKHERJI, A.; MUKHERJEE, R.; ARIMA, S.; HARIGAYA, Y.; Tetrahedron Lett. 48 (2007) 30, 5239-5242; Dep. Chem., Bose Inst., Kolkata 700 009, India; Eng.) -Mais 45-124