The outbreak of the SARS-C0V-2 pandemic has continued to affect people's lives on a global scale. When the number of infected cases decreased, several countries across the world lifted their lock-down controls and started to open. But the latest re-emergence of COVID-19 cases across Europe once again prompted nations to step back to contain the virus spread. The most prevalent route of transmission is through aerosols and droplet inhalation, which is crucial for dental health workers as most dental procedures generate significant amounts of droplets and aerosols. Thus, it is imperative to follow infection control strategies and patient management protocols to ensure optimum dental care and at the same time prevent nosocomial infection in dental settings. This review provides an insight into the steps taken for infection control and prevention from COVID-19 transmission in endodontic practices.