From the last two decades, phthalimide analogues received prime interest from scientists due to its potent inhibitory action on different cancer-causing receptors. A variety of anticancer drugs are coming into the market but challenges of drug resistance, toxicities, and failure in therapy still remain. Cancer is a group of complex disorders it involves multiple receptors. So there is a need of targeting multiple receptors to get desired potent anticancer drugs with minimum harmful effects. Phthalimide scaffolds fit into these criteria as it is extensively reported for the inhibition of different cancer receptors such as VEGFR, HDAC, EGFR, TNF-α, etc. The multi-targeted mechanism of phthalimide derivatives plays a major role in anticancer therapy. Due to this advantage, there is the hope of developing some novel effective multi-targeted anticancer agents. Consider structural features and pharmacological advancement of phthalimide analogues may fulfill the current need of cancer patients. In this review, we covered history, chemistry, SAR, anticancer mechanisms, and the current status of phthalimide derivatives reported till 2022. The article specifically focused on different cancer-causing receptors inhibited by phthalimide derivatives and their mechanism of action in brief. Finally, we provided the future scope and role of phthalimide derivatives in multi-targeted anticancer drug discovery.

Pollutants or novel entities are the atoms, molecules, and particles that come up with as pollution. This paper discusses the several ways that pollutants can enter the environment, both naturally and via human activity. There exist several kinds of pollutant which includes primary pollutant, secondary pollutant, water pollutants, anthropogenic contaminants, pharmaceuticals, and personal care products contaminants, pollutants from agricultural products, contaminants from narcotics and other drugs, personal care products, contaminants from the food industry and microplastics are present just in the environment possess severe dangers to human health and aquatic creatures. Our study aims to demonstrate the imperative need to detect substances that could pose a concern to receptors from an analytical standpoint, new techniques must be developed. Additionally, it is necessary to construct a more thorough environmental risk assessment. To this objective, chemical and biological analyses have to be coupled to get a better evaluation of the harm that Emerging contaminants does to the environment.

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