Our findings suggest that cough itself is a traumatic mechanical stress to the airway wall that induces neutrophilic airway inflammation and cough-reflex hypersensitivity. Cough stress to the airway wall results in a self-perpetuating cough-reflex cycle.

Background Detecting and addressing aspiration early in children with dysphagia, such as those with cerebral palsy, is important for preventing aspiration pneumonia. The current gold standards for assessing aspiration are swallowing function tests, such as fiberoptic endoscopic evaluation of swallowing (FEES) and videofluorographic swallowing study; however, the relationship between aspiration of secretion vs aspiration of foodstuff and pulmonary injury is unclear. To clarify this relationship, we examined the correlations between pneumonia findings from chest computed tomography (CT) and the presence or absence of aspiration detected by FEES. Methods Eighty-five children (11 years 2 months ±7 years 2 months) underwent FEES and chest CT. Based on the FEES findings, the participants were divided into groups: with and without food aspiration, and with and without saliva aspiration. Correlations between chest CT findings of pneumonia and the presence or absence of each type of aspiration were then examined. Results No significant correlations were observed between food aspiration and chest CT findings of pneumonia, whereas saliva aspiration and chest CT findings of pneumonia were significantly correlated. In addition, saliva aspiration was significantly associated with bronchial wall thickening ( p < 0.01) and atelectasis ( p < 0.05). Conclusions Our findings in children suggest that: (1) the presence or absence of food aspiration detected by FEES evaluation has little correlation with pneumonia, and (2) the presence or absence of saliva aspiration may be an indicator of aspiration pneumonia risk.

Abstract

We examined the effectiveness of trivalent influenza vaccine in reducing illness, absenteeism, and health care use among health-care workers (HCW) of Ishikawa Prefectural Central Hospital from December 1999 through March 2000. In recipients of vaccine (n = 132), the numbers of febrile illness, severe illness, febrile upper respiratory tract illness were significantly reduced compared with HCW without vaccination (n = 595). Use of prescription antibiotics and over-the-counter medications was also reduced. Influenza vaccine also reduced the reported days of work absence. These data support a policy of annual influenza vaccination of HCW.

In recent years, an unshrouded impeller is being developed for rocket turbopumps to reduce production costs and disk friction losses. However, the internal flow structure in a diffuser influenced by an impeller has not been clarified yet. In this study, we focused on the investigation of unsteady flow in turbopumps with unshrouded impellers and vaned diffusers by experiments and CFD. Furthermore, we investigated the effect of changing the number of blades of the impeller and diffuser on the unsteady losses in the diffuser. First, we measured the static pressure at the shroud side in the impeller and the velocity at the diffuser inlet and outlet. Second, we confirmed the accuracy of the CFD by comparing CFD results with experimental results. Third, we investigated unsteady losses in diffusers by CFD. We could confirm increased entropy at the suction surface and shroud side because of the tip leakage and the vortex. Finally, we changed the number of impeller blades or diffuser blades. In conclusion, the loss region at the suction surface and the high-pressure region at pressure surface in the unshrouded impeller were mixed and caused unsteady losses through the diffuser. And diffuser efficiency decreased because channel width in diffuser became narrower by the number of diffuser blades increasing.