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A temperature-sensitive mutant, strain SS, which is assumed to be devoid of β-lactamase activity and deficient in a permeability barrier to antibiotics, was isolated from a β-lactamase-less mutant, strain L-2, derived from Pseudomonas aeruginosa IFO 3080. By comparing the β-lactam antibiotic susceptibility between strains IFO 3080, L-2, and SS, the involvement of both β-lactamase and a permeability barrier in determining the β-lactam antibiotic resistance was estimated.

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