No abstract

2-Cyano-1-t-butylethyl or 2-cyano-1-(1,1-diethyl-3-butenyl)ethyl 3′-O-phosphorimidazolidite of 5′-O-protected nucleoside was prepared in situ by the use of 2-cyano-1-t-butylethyl or 2-cyano-1-(1,1-diethyl-3-butenyl)ethyl phosphorobisimidazolidite as a new phosphitylating reagent. The phosphorimidazolidites were found to be key intermediates for preparing 5′-O-protected nucleoside 3′-O-monoalkylphosphoramidites in situ useful in the solid-phase oligonucleotide synthesis, and for synthesizing conveniently 3′-OH free dinucleoside phosphates and phosphorothioates in solution.

No abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.