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We have developed a novel micro optical diffusion sensor (MODS) based on a laser induced dielectrophoresis (LIDEP) enabling small sample volume, high-speed measurement and on-site sensing of the protein conformation. This paper reports the measurement principle, chip design, and the validity of the proposed method. In order to verify the applicability of MODS, we confirmed the sinusoidal concentration distribution of polystyrene beads in distilled water generated by LIDEP force. The decay time of the diffusion of the concentration distribution agreed well with the theoretical calculation. As a result, the applicability of MODS as the diffusion coefficient measurement method was verified.

No abstract

No abstract

We have developed a novel micro optical diffusion sensor (MODS) based on laser-induced dielectrophoresis (LIDEP), which enables rapid measurement with a small sample volume and on-site sensing of protein conformation. This paper presents the measurement principle, the chip design, and the validity of the proposed method. To verify the applicability of MODS, we confirmed a sinusoidal concentration distribution of polystyrene beads in a surface-modified microchannel generated by LIDEP force. The decay time of the diffusion of the concentration distribution agreed well with theoretical calculations, confirming the applicability of MODS as a technique for measuring the diffusion coefficient.