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Endodontic pain is one of the most predominantly associated symptoms. The pain may arise due to either because of an endodontic cause (or) a periradicular cause, importantly endodontic pain type variant is the most commonly encountered by the dentist in their clinical practice. The objective of endodontic treatment is to prevent or cure apical periodontitis (AP) caused by infection of the root canal systems of the affected teeth (or) due to persistence of primary infection (or) emergence of infection after treatment 1. An online search was conducted in MEDLINE, Embase, the Cochrane library and the cumulative Index to Nursing and Allied Health literature to retrieve evidence on benefits and harm associated with antibiotic use & review articles by utilizing the following keywords: Antibiotics, symptomatic Irreversible pulpitis, symptomatic apical periodontitis, pulp necrosis, localized acute apical abscess, clinical practice guidelines. The clinician must systematically gather all of the necessary information to make a “probable diagnosis” Endodontic diagnosis is similar to a Jigsaw puzzle diagnosis cannot be made from a single isolated piece of information. The indications are based on the clinical diagnosis of Normal pulp, reversible pulpitis, symptomatic (or) asymptomatic Irreversible pulpitis & necrotic pulp (or) localized acute apical abscess 2.