Tuberculosis (TB) is a shocking problem for the least developed and low income country like Bangladesh caused by M. tuberculosis, M. bovis, M. africanum, and M. microti infection with ID 50 1-10. Bangladesh holding the 6 th position among the 22 countries with highest TB burden and the incidence per 100,000 people was 220 in 2008. Even there is no estimation on the prevalence of childhood TB and is severely under-diagnosed. A descriptive type of cross sectional study was conducted to assess the mothers' knowledge and awareness of TB and Childhood TB during September, 2013 to February, 2014 with the sample size 106. The study population was those, who came to outpatient department of the Bangladesh Government Homeopathic Medical College Hospital with age limit of between 18-35 years for treatment and had at least one child below five years. Among the respondents frustratingly 84% had no idea about childhood TB and they not even concerned about it where some of them said "Babies are the gift of Allah (God) and He has the responsibility to save the baby". The analysis showed respondents' with <25 years had more knowledge than >25 years age group (x 2 =1.91: P-value-0.l67). 55.3% Respondents had no idea about where to diagnose TB and the respondents with high literacy rate had significantly more knowledge about TB and Childhood TB than illiterate (x 2 =4.050: P-value-0.04). Analysis also showed housewives had relatively poor knowledge about TB and childhood TB (x 2 =0.0 19; P-value-0.891) and having income >9,000 taka/month had significantly more knowledge about TB and Childhood TB (x 2 =27.786; P-value-0.00l). The study findings suggested that the strategy of TB control should be more effective and target oriented than the other countries and should make a health intervention policy for Bangladesh to manage the infectious diseases.