The drug delivery system was effective against MRSA-induced osteomyelitis without negative effect on osteointegration. This biodegradable technology has the potential to be a powerful tool in fighting bone infections.

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Biofilm-forming Staphylococcus epidermidis strains are common cause of the periprosthetic infection. The treatment of the periprosthetic infection is very problematic, so the prevention of these infections by an antibiotic containing prothesis could be an option for prevention.The purpose of the present study was to examine the in vitro effects of drug delivery systems (DDSs), namely Wax 1 and Wax 2 with different vancomycin content: 0.5, 1, 2 and 4 mg. In order to control the antibacterial activity of DDSs killing curve study was performed and in order to determine the antibiotic release and the antibiotic peak concentration from the DDSs biological assay was carried out.The time kill curve studies showed, that both DDSs with all vancomycin concentration decreased significantly the bacterial counts, however, Wax 2 with 4 mg vancomycin significantly decreased the bacterial count than all the other groups.The vancomycin release was the best with the highest peak concentration from DDSs with 4 mg vancomycin contain; it was significantly better than in the other groups, however, no significant difference was observed between Wax 1 and Wax 2 in this respect.These findings suggest that Wax 2 with 4 mg vancomycin content could be a potential agent for clinical use.

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In Hungary about 1900-2500 new patients suffering from tuberculosis have been registered yearly in the last few years. In 2000 the incidence was 36/100,000, which decreased to 18.8/100,000 by the year 2006. Extrapulmonary, skeletal forms are uncommon and develop in a slow way, therefore the specific diagnostic steps are not part of the daily routine orthopedic examination. To provide appropriate diagnosis and successful treatment, the cooperative work of many faculties is essential. Authors report a case of a 19-year-old male patient with hip complaints in the last two years. X-ray, CT and MRI examinations proved a progressive pattern of destruction of the hip joint. Diagnostic steps and failures, also the surgical therapeutic solution of active hip tuberculosis, have been presented.