Laryngoscopy and tracheal intubation are nearly always associated with an increase in the blood pressure and an increase in heart rate due to reflex sympathetic discharge which is caused by epipharyngeal and laryngopharyngeal stimulation. In recent years the laparoscopic surgery which once upon a time were considered to cause least trauma are reported to have hemodynamic instability. Conclusively during general anesthesia, it is desirable to have a stable intraoperative hemodynamic status. Hence in this study, it has been attempted to compare the beneficial effect and also side effect of the two a2-agonist clonidine and De0zxmedetomidine in maintaining the perioperative parameters like MAP, heart rate.