A series of 1, 5-benzodiazepines were synthesized by condensation of o-phenylenediamine with different ketones and effect of different aliphatic acids used as catalyst was studied. Among the various acids screened, chloroacetic acid came out to be a versatile catalyst and the corresponding products were obtained in good to excellent isolated yields (85-94%) under solvent free conditions.

A series of 2,3-dihydro-1H-1,5-benzodiazepines derivatives were synthesized by one-pot three-components condensation reaction of o-phenylenediamines with α,β-unsaturated carbonyl compounds and effect of various Brønsted organo acids as catalyst was studied. Among the various organo acids screened, trifluoroacetic acid is versatile catalyst and the corresponding products were obtained in good to excellent yield (84-94 %) under solvent-free condition.

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