Background: Nephropathy is a significant complication of diabetes mellitus, which is associated with high morbidity and mortality. Exercise training has been shown to have renoprotective effects in diabetes. Unregulated vascular endothelial growth factor (VEGF) has been demonstrated in the diabetic kidney. Thus, the aim of our study is to illustrate the impact of endurance exercise training on the renal VEGF expression in type I diabetic rats.

Background: Diabetes is associated with a marked increase in the risk of cardiac diseases, including atherosclerosis, cardiomyopathy, and impaired ventricular function. The ability of exercise to reduce the risk of cardiac troubles has been established, but no studies have examined this link in type 1 diabetes. A randomized, controlled animal study was designed using a standard rat model of type 1 diabetes. The goal of this study was to investigate the expression of P53 and iNOS in cardiac muscle of rat with Alloxan-induced diabetes.