Purpose: To investigate the in vitro antiproliferative activity of methanol extracts of six plants regardless of their claimed ethnopharmacological application. Methods: Methanol extracts of different parts of Glycyrrhiza glabra L. Licorice), Matricaria chamomilla L. (Chamomile), Salvia triloba L. (Sage), Rheum palmatum L. (Rhubarb), Trigonella foenum-graecum L (Fenugreek) and Sambucus ebulus L. (Dwarf Elder)were prepared. The antiproliferative effects of the extracts weretestedon two skin cancer melanoma cell lines namely A375.S2 (low tyrosinase expression) and WM 136.1A (high tyrosinase expression) using MTT assay.The IC50 values for the active extracts were determined against the two melanoma cell lines. Results: The methanol extracts of G. glabra, M. chamomilla, S.triloba, R. palmatum inhibited the melanotic WM1361A proliferation in a dose-dependent manner revealing IC 50 values of 35.2, 25.2, 20.6, 17.8, µg/ml, respectively but not A375.S2 cell line. However, the extracts of T. foenum-graecum and S. ebulus did not exhibit any significant cytotoxic activity on both melanoma cell lines. Conclusion: Methanol extracts of Licorice, Chamomile, Sage and Rhubarb have significant antiproliferative activity on WM1361A cell line; a representative human melanotic melanocyte tumor cell line. This renders these plants as potential sources of new lead compounds for the development of new drugs for melanoma cancer.

The aim of the current study was to investigate the invitro antiproliferative activity of methanolic extracts of six plants regardless of their claimed ethnopharmacological application. Methods: Methanol extracts of different parts of Glycyrrhizaglabra L. (Licorice),Matricariachamomilla L. (Chamomile), Salvia triloba L. (Sage), Rheum palmatum L. (Rhubarb), Trigonellafoenum-graecumL. (Fenugreek) and Sambucusebulus L. (Dwarf Elder) were prepared. The antiproliferative effects of the extracts were tested on two skin cancer melanoma cell lines namely A375.S2 (low tyrosinase expression) and WM 136.1A (high tyrosinase expression) using MTT assay. The IC50 values for the active extracts were determined against the two melanoma cell lines.

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The aim of this study was to detect the level of optimism and pessimism and its relation to the quality of life in patients with renal failure in the government and private hospitals in Irbid in light of the variables: gender, age, duration of disease and educational level of patients, the sample of the study consisted of (93) patients with kidney failure, who were randomly selected from the study population. The researchers used optimism and pessimism scale and the quality of life scales, their validity and reliability were verified. Results of the study showed that the means for optimism scale ranged between (3.602-3.075) with a medium degree, and the means for pessimism scale ranged between (4.086-3.118) with a high and medium degree, while the means for quality of life scale ranged between (4.054-2.957) with a high and medium degree. Results also showed the existence of a correlation between the level of optimism and the level of quality of life and this relationship is a moderate relationship, and a lack of correlation between level of optimism and level of pessimism and level of pessimism and quality of life. There are no statistically significant differences at the level of significance (0.05) in the patients' responses on the optimism, pessimism scales according to (gender, family income, medical insurance and origin).