Aim:To evaluate the effectiveness of Solcoseryl on bone regeneration in rabbit calvarial bony defect through histological examination and histomorphometric analysis. Materials and Methods: Twenty New Zealand rabbits were divided into 4 groups. Two cavities were drilled in the calvarial bone of each rabbit. Defects were left empty in group A as a control group or filled with either Solcoseryl in group B, DM Bone in group C or (Solcoseryl & DM Bone) mixture in group D. Rabbits were sacrificed on day 14; the defects were removed and prepared for histological and histomorphometric analysis. The area percent of newly formed bone was estimated. Comparison of the results of all groups were statistically analyzed by ANOVA and Post-hoc tests. Results: Histological evaluation revealed presence of granulation tissues in control group while woven bone formation was evident in all experimental groups with evident osteoid tissue in group C & D. Histomorphometric analysis revealed that the quantity of newly formed bone was the greatest in mixture group. The greatest area percent of uncalcified bone was recorded in control. Conclusion: Combination of Solcoseryl and DM Bone has a synergistic effect on bone formation quantitatively and qualitatively.