This study aims to examine the effects of anemia on patients with diabetes mellitus type II (DM). The cross-sectional study included 75 patients with (DM). They were divided into two groups according to the presence of anemia. The first group includes 50 diabetic patients suffering from anemia, while the second group contains only 25 patients with diabetes only. There was no specification in gender; the patients included both sexes and their ages were above 20 years. A blood sample was collected from each patient to measure (fasting blood glucose, hemoglobin, glycosylated hemoglobin, and ferritin). The results revealed an increase in anemia in females with diabetes mellitus more than males while the levels of HbA1c was on the contrary; it increased in males and decreased in females. A significant negative correlation is confirmed between ferritin and HbA1c in anemic diabetic women. Diabetic patients suffering from anemia recorded a sharp decrease in the levels of ferritin compared with patients with diabetes only. In conclusion, the incidence of anemia increase in diabetic patients with increased levels of HbA1c.