A degenerate zinc-templated
catalytic system containing two bipyridine
ligands with redundant functional groups for either enamine or hydrogen
bond formation was applied to the asymmetric aldol reaction. This
concept led to both a higher probability of reaction and rate acceleration.
Thus, the catalyst loading could be decreased to a remarkable 2 mol
% in what we think is a general approach.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.