This study confirms two factors about menopausal hormonal migraine: (1) it can be precipitated by a drop in serum estrogen levels, and (2) a period of estrogen priming is a necessary prerequisite. This study also identifies that there are two biologically different populations of postmenopausal women: (1) those who developed migraine after a single depo-estradiol injection, and (2) those who did not. By understanding that in addition to the biological predisposition to migraine there exists the biochemical cofactor of falling estrogen levels, we may better understand this phenomenon and develop means to prevent its occurrence.

No abstract

This paper describes some histologic and histochemical characteristics of an easily transplantable islet-cell tumor of the Syrian hamster. The presence of insulin was demonstrated by means of fluorescent antibody and immunoassay technics. A positive histochemical reaction for tryptophan suggests, but does not prove, the presence of small amounts of glucagon. It is suggested that the tumor may be a useful tool for biologic studies. DIABETES 16:409-14, June, 1967.