The primary purpose of this study is to understand the factors that affect Latino student adjustment in the first and second year of college. The study examines data from a national, Iongitudinal survey along with the Student Adaptation to College Questionnaire completed by Latino students judged to have high potential for success upon entering a variety of four-year colleges. Results show dimensions of the campus climate affect all forms of student adjustment, as do transitional experiences that are common to most students in the first year. Implications of the findings suggest further college programming and monitoring of adjustment in the second year of college.