A digitalization of business process through utilizing Digital Twins is an approach that assists companies to align themselves with changes of technology development, and accordingly, improve their outcomes. To take full advantage of implementing Digital Twins, the importance of the creative phase role as pillars of this technology on the performance of the other parts and overall outcome should not be overlooked. This research addresses the lack of an integrated framework for setting up the creative phase of digital twins. To design the proper framework, by relying on a qualitative empirical method, an interview with persons who are experts in the Digital Twin area was organized to collect the information about all obvious and hidden aspects of this phase and manifest what kind of entities participate in this phase, what potential challenges and obstacles exist and what solution is effective to overcome them. The structural feature of the proposed framework continuously prepares the system for changes, aiming to adopt improvement within. The findings of this study can be used as instruction by all companies that want to take the first steps toward the digital representation of physical assets, or for those who deal with Digital Twin and want to improve their systems’ interactions.