In women with premature ovarian insufficiency (POI), ovarian function is impaired prior to forty years of age, with a loss of ovarian reserve and a reduction in the production of sex steroids. 1-3 The condition of early hypoestrogenism clinically manifests as irregular menstrual cycles with primary or secondary amenorrhoea, expressed as hypergonadotropic hypogonadism, with FSH levels above 25 IU/L. 1,2 This condition affects
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