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Effective Synthesis of Enantiopure [1,2,3]Triazolo[1,5-a]-and Pyrazolo[1,5-a]-pyrrolo[2,1-c][1,4]benzodiazepines by Diastereoselective Intramolecular Azide and Nitrilimine Cycloadditions S y n t h e s i s o f [ 1 , 2 , 3 ] T r i a z o l o [ 1 , 5 -a ] -a n d P y r a z o l o [ 1 , 5 -a ] -p y r r o l o [ 2 , 1 -c ] [ 1 , 4 ] b e n z o d i a z e p i n e s Abstract:The synthesis of new tetracyclic 1,4-benzodiazepinonic systems was performed in enantiopure form by totally diastereoselective intramolecular 1,3-dipolar cycloadditions. The absolute stereochemistry of the products was confirmed by X-ray crystallography and the enantiomeric purity was determined by using chiral HPLC.

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