Die Na‐Boc‐geschützten Aminosäuren L‐Lysin und L‐Ornithin werden mit den entsprechenden Hydroxybenzophenonen in die Ne‐geschützten Aminosäuren (Ia) (78% Ausb.) bzw. (Ib) (45% des Dicyclohexylammoniumsalzes) übergeführt.

Nα-t-Butoxycarbonyl-Nε-(2-hydroxyarylmethylene)-ornithine and -lysine have been synthesized and coupled with amino acyl resins in the presence of dicyclohexylcarbodiimide to form N-protected peptide resin esters. The ketimine protecting group was found to be stable under anhydrous conditions and the urethane blocking group could be removed preferentially. A number of lysine- and ornithine- containing peptides have been synthesized by the solid-phase technique.