Both IIS are safe and effective. The 2 IIS did not differ from each other with respect to pain observed during insertion.

This observational study provides evidence from a real-life setting that BOT with insulin glargine provides slightly greater reductions in weight, FBG and HbA1c levels, with a lower risk of hypoglycaemia than patients receiving NPH. This conclusion indicates that insulin glargine may be preferable to NPH insulin for BOT.

No abstract

The analysis of the lactatdehydrogenase (LDH)-isoenzym patterns in normal human cartilage will be of valuable help in the interpretation of enzymological data in cases of pathological joint changes. It may allow conclusions about the situation of the metabolism in a joint according to the particular circumstances. As so far no representative investigations into normal human cartilage have become known, the attempt has been made in this paper to evaluate the LDH-isoenzym pattern in normal cartilage. The result indicates that in normal human joint cartilage the LDH-5 dominates with an average of 75.3%, whereas the LDH-4 (21.7%) and the LDH-3 (3.2%) are considerably lower. Thus the result fits well into the joint cartilage data which have been published so far.