Nota: Artículo recibido el 16 de febrero de 2015 y aceptado el 06 de mayo de 2015. ARTÍCULO ORIGINAL RESUMENSe desarrolló y optimizó un método por Microextracción en Fase Sólida seguido de Cromatografía de GasesEspectrometría de Masas (MEFS-CG-EM) para la determinación de ibuprofeno, naproxeno, clorofeno, triclosán y bisfenol A catalogados dentro de los contaminantes emergentes o productos farmacéuticos de cuidado personal (PPCP's, por sus siglas en inglés) en aguas residuales. La extracción de los analitos se realizó por MEFS utilizando la Zona metropolitana de la Ciudad de México. Se demostró en este trabajo que la MEFS es una técnica de preparación de muestra simple, reproducible, sensible y rápida, ya que reduce etapas al extraer y concentrar Palabras Clave: Análisis de aguas residuales, MEFS-CG-EM, productos farmacéuticos de cuidado personal. ABSTRACTKey Words: Wastewater analysis, SPME-GC-MS, PPCP's analysis,

A whole-body permeability-rate-limited physiologically based pharmacokinetic (PBPK) model for cocaine was developed with the aim to predict the concentration–time profiles of the drug in blood and different tissues in humans.

Malathion is a widely used organophosphorus pesticide; it is also a molecule of forensic interest due to its moderate to high toxicity in nontarget organisms, humans included. This compound is present in some fatal intoxications, accidental or intentional; its presence in the tissues on which the cadaveric entomofauna feeds may affect its growth rate and life cycle duration leading to an error in the estimation of the minimum postmortem interval (PMImin). Since the toxic effect of malathion on the cadaveric entomofauna could affect the estimation of the PMImin, the aim of this work was to study the toxic effect of malathion on the growth and development of the scuttle fly, Megaselia scalaris, a fly of forensic interest which plays an important role in forensics cases related to human remains found indoors or in concealed environments. The study was complemented with some morphological observations; no morphological changes were observed in the larvae, nor the adult flies exposed to malathion. Malathion affects the viability of the egg and pupa, it also reduces the larval growth rate and increases the duration of the larval stage; therefore, the estimation of the PMImin, with this species when malathion is present in tissues, could be affected.

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