Research Article IJOAR (2019) 2:53 Use and preventive value of metformin in geriatric women with polycystic ovary syndrome Objective: To establish the effects of long-term use and preventive value of metformin in geriatric women with PCOS. Methods: A search of published review articles was carried out in sites such as NCBI, ScienceDirect, Elsevier, Springer, Wolters Kluwer, among others, using the key words: "polycystic ovary syndrome", "PCOS", "Polycystic ovary syndrome and metformin", " effects of metformin and PCOS "," insulin resistance and metformin "and" long-term sequelae of polycystic ovarian syndrome ". Results: We retrospectively analyzed data specific to the randomized clinical trial of Pedersen et al. 2017, to determine the impact that treatment had for twelve months with metformin in three specific variables: weight, total cholesterol and HDL. The study was conducted in 40 Caucasian women from 18 to 39 years of age, with a fixed dose of metformin (2 g / day for 12 months), who met the Rotterdam criteria for PCOS in their genetic variant MATE1 with SOP7 Conclusions: It was confirmed that the establishment of twelvemonth treatment with metformin in the randomized clinical trial of Pedersen et al. 2017 had a significant effect on the three specific variables: weight, total cholesterol and HDL.

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