Cycloaddition. -Significant amounts (20-45% NMR) of undesired regioisomers are also generated in some cases. -(MORI, A.; ARAKI, T.; MIYAUCHI, Y.; NOGUCHI, K.; TANAKA*, K.; Eur.

In this work, we investigated the effects of Casiopeina II-gly (Cas IIgly)--a new copper compound exhibiting antineoplastic activity--on glioma C6 cells under both in vitro and in vivo conditions, as an approach to identify potential therapeutic agents against malignant glioma. The exposure of C6 cells to Cas IIgly significantly inhibited cell proliferation, increased reactive oxygen species (ROS) formation, and induced apoptosis in a dose-dependent manner. In cultured C6 cells, Cas IIgly caused mitochondrio-nuclear translocation of apoptosis induction factor (AIF) and endonuclease G at all concentrations tested; in contrast, fragmentation of nucleosomal DNA, cytochrome c release, and caspase-3 activation were observed at high concentrations. Administration of N-acetyl-L-cystein, an antioxidant, resulted in significant inhibition of AIF translocation, nucleosomal DNA fragmentation, and caspase-3 activation induced by Cas IIgly. These results suggest that caspase-dependent and caspase-independent pathways both participate in apoptotic events elicited by Cas IIgly. ROS formation induced by Cas IIgly might also be involved in the mitochondrio-nuclear translocation of AIF and apoptosis. In addition, treatment of glioma C6-positive rats with Cas IIgly reduced tumor volume and mitotic and cell proliferation indexes, and increased apoptotic index. Our findings support the use of Cas IIgly for the treatment of malignant gliomas.

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The operation of an anaerobic/aerobic process used to degrade the colorants present in textile wastewater is presented. The objective is to produce water that can be reused. Two particular cases were studied: the degradation of a synthetic wastewater containing the colorant disperse blue 79 (DB79) as a model compound and a real textile effluent containing reactive azo dyes. The biodegradation was achieved using a single tank operated as sequencing batch reactor. It was observed that the DB79 was biotransformed to amines in the anaerobic stage decolorizing the wastewater. The amines formed were subsequently mineralized in the aerobic phase. An increase of toxicity was observed in the anaerobic stage due to the amines formation, but the wastewater was detoxified after the aerobic treatment. Removal efficiencies of DB79 around 92% were observed after the treatment. Around 96% of the initial color of the real wastewater was effectively removed. It was observed that the biomass pre-acclimatized to the degradation of DB79 was more effective for the color removal than a freshly inoculum used.

Versión en español AbstractPurpose: This paper makes a literature review in order to analyze the current state of innovation in tourism companies and know the future research lines on the subject.Design/methodology: The study chose a content analysis, which purpose was to examine the scientific journal articles about tourism, business management and economic-administrative studies, considering ScienceDirect, Taylor & Francis, EBSCOHost and REDALYC databases.The procedure involves filtering papers based on criteria of relevance as addressing the issue and current facts (texts inscribed in the period 2008-2015). As a result 78 publications based on bibliographic content matrices were analyzed and classified according to their thematic profile.Moreover, a search for bases outside the above data was done, in order to know the situation of tourism companies in the Mexican context. Findings:The review shows that papers are concentrated in six broad categories: a) organizational innovation, b) innovation strategies, c) innovation in products and processes, d) technological innovation, e) knowledge management in innovation and f) innovation models.Most studies are given in the context of hotels and restaurants; showing that innovation in -1088-Intangible Capital -http://dx.doi.org/10. 3926/ic.778 tourism companies is an emerging theme study that will strengthen the development and competitiveness of the sector itself. Originality/value: It represents an innovative contribution by providing information on how ithas been addressed the issue of innovation in the context of tourism companies -restaurants and hotels-, besides provides an overview of research conducted in Mexico on the topic, being of interest to the companies and academic community. Jel Codes: M10, O30, Z31Intangible Capital -http://dx.doi.org/10. 3926/ic.778 search, selection and analysis of research; after the results according to the main topics in innovation in tourism companies are presented. Subsequently, the contributions in the Mexican context are presented. Finally, the conclusions and future research lines are showed.