The article presents the results of research aimed at the creation of highly sensitive, compact and inexpensive biosensor analyzers based on differential conductometry. The main factors, which reduce the sensitivity of the measuring channel and cause the measurement errors, are considered; the measurement methods to eliminate or minimize their effect are discussed. The results of theoretical and experimental studies of conductometric converters of biosensors and measuring circuits are presented. The technical realization of these methods is proposed; the important characteristics of the sensors and the developed devices are described, as well as the outcomes obtained at their approbation.