Исследование было одобрено этическим комитетом Самарского областного клинического онкологического диспансера. В ретроспективный анализ включили результаты лечения 550 больных с доброкачественными новообразованиями щитовидной железы, получивших лечение в 2014-2015 гг. Из них 304 пациентам выполнена РЧА, 246-хирургическая операция (ХО). В 1-ю группу вошли 263 пациента без гипертиреоза со следующими клиническими проявлениями: синдром сдавления, затруднение дыхания, чувство дискомфорта в Махонин Александр Александрович-зав. онкологическим отд. №2 (лечение головы, шеи) Самарского областного клинического онкологического диспансера. Самара, Россия

The immune system plays a key role in the development and progression of head and neck squamous cell carcinoma. Understanding the dysregulation and blockage of the immune system of malignant tumors in this location can improve treatment outcomes. A special group is made up of patients who have a widespread process and relapse after chemotherapy with platinum drugs, because they have a very poor prognosis and limitations in the possibilities of further treatment. To date, the most important data relate to drugs acting on the PD-1 (programmed cell death protein 1)/PD-L1 (programmed death ligand 1) immune checkpoints, which are used by the tumor to block the immune system, which have allowed to increase the effectiveness of treatment. The article presents a clinical case demonstrating the effectiveness of the use of checkpoint inhibitors after the use of platinum preparations.

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Aim - to evaluate the effectiveness of voice rehabilitation with the use of voice prosthesis, and to review the existing methods of voice rehabilitation with their advantages and disadvantages in order to define the most effective one. Materials and methods. 26 clinical cases include patients aged 54-70 years who underwent laryngectomy as a part of the throat cancer treatment. Voice prostheses were used for their rehabilitation. Results. Tracheoesophageal shunting with voice prosthesis has remarkable advantages over the other methods of restoring the normal voice function.