A 24-year-old male patient, who underwent kidney transplant six years ago due to
Lupus nephritis, for the last two years presented asymptomatic erythematous scaly
plaques on the abdomen and areas exposed to light. Post-transplantation
immunosuppressive medications included prednisone, mycophenolate sodium and
sirolimus. The histopathologic features were typical for epidermodysplasia
verruciformis. Epidermodysplasia verruciformis is a rare autosomal recessive
genodermatosis with increased susceptibility to specific strains of cutaneous human
papilloma virus. The term ''acquired epidermodysplasia verruciformis'' was recently
introduced to the literature and describes epidermodysplasia verruciformis occurring
in patients with impaired cell-mediated immunity. We report an additional case
associated to immunosuppression after kidney transplantation.
Netherton syndrome is a rare autosomal recessive disease characterized by
erythroderma, ichthyosis linearis circumflexa, atopy, failure to thrive and a
specific hair shaft abnormality called trichorrhexis invaginata or bamboo hair,
considered pathognomonic. We report the case of a 4-year-old boy with
erythroderma since birth, growth deficit and chronic diarrhea. Trichoscopy was
used to visualize typical bamboo and "golf tee" hair and of key importance to
diagnose Netherton syndrome. We suggest the use of this procedure in all
children diagnosed with erythroderma.
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